Link Between Statins And Diabetes

Share on facebook

Cholesterol-lowering Statin Linked To Heightened Diabetes Risk

A US study has linked the cholesterol-lowering drug statin to a heightened risk of type 2 diabetes among patients already deemed to be at high risk of the condition. Published in the journal BMJ Open Diabetes Research and Care, the study looked at data from 3,234 overweight or obese participants taking part in the US Diabetes Prevention Programme Outcomes Study. After 10 years follow-up, a third of patients had started using statins. Researchers found that taking the drugs was associated with a 36% heightened risk of being diagnosed with type 2 diabetes, compared to those who had not been prescribed. "This study indicates that statins can increase the onset of diabetes in some people,” said Professor Jeremy Pearson, associate medical director at the British Heart Foundation. "However, it does not mean that people should stop taking their statins as there is no doubt they save lives. Instead, the findings reinforce the need to regularly monitor the blood sugar levels of patients taking statins." In a separate study, British researchers found a “significant” number of patients prescribed statins only had a small chance of developing cardiovascular disease (CVD) The report, publ Continue reading >>

Share on facebook

Popular Questions

  1. Sam19

    Originally Posted by ethornhill
    If I can keep my A1C within the normal range, can I avoid complications all together?
    I know that everybody gets those complications as they age. However, will I face the same odds as those non-diabetic people, if I can keep my A1C under control? And it's not entirely understood if blood glucose levels and variations are the sole mechanism that causes complications... they are certainly the sole one we have much control over though
    Sent from my iPhone using Diabetes Daily

  2. jdm1217

    Originally Posted by ronpfid
    In one respect, yes if your glucose is actually identical to a non D, then your glucose wouldn't be increasing your odds at complication. But of course, non D's can get these things too, so it wouldn't be zero chance, it would just be what ever your personal odds are with normal BG's, which of course is lower than your odds if your BG's were higher. Except some complications may go back to other things besides just circulating glucose. For example, in the above case it might be relevant HOW you got normal blood sugar. As a T2 (unless very late stage) you would have BOTH high glucose and high insulin, compared to a non-diabetic. If you achieve normal glucose by raising insulin even more, there is nothing "normal" about your state. You have merely exchanged high glucose for even higher insulin. And this high insulin is suspected of being directly involved in at least some diabetic complications, specifically CVD. High circulating glucose is CORRELATED with complications, but direct causation is far from established.
    Complications could also relate to total glucose PROCESSED and not just the "excess" or circulating one that we can measure. T2s have issues with alpha cells which secrete too much glucagon triggering de novo gluconeogenesis (manufacture of NEW glucose from non-carbohydrate substrates) in the liver and secretion of glucose by the liver into the blood. Insulin resistance of the liver itself means it fails to get the message to STOP doing this. This makes the total amount of glucose higher even somewhat independent of diet. So, even if you manage to force this extra glucose into cells until you get "normal" LEFTOVER glucose (the one we measure), this is still not a "normal" state all things considered.
    If, on the other hand, you can achieve normal glucose AND normal insulin, then this as far as we know resembles the condition of a non-diabetic and there is no relevant feature - that we know of - that would make this condition any different from a non-diabetic. Your diabetes at that point is only "virtual", rather like the peanut allergy of someone who hasn't and isn't coming in contact with peanuts. Still "virtually" allergic to peanuts, but there is zero physical manifestation or impact on health. The same cannot be said for all-normal blood sugar if it is achieved/maintained by abnormally high insulin (either endogenous or injected).
    So, normal glucose but even higher insulin MIGHT be an improvement, but it is not the "normal" condition of a non-diabetic.

  3. jwags

    My ENDO told me that 25% of diabetics are prone to complicstions even with pre diabetic HbA1 c's. So it is hard to tell who gets complications and who doesn't. I have had eye complications since my initial dx.

  4. -> Continue reading
read more close

Related Articles

  • Link Between Statins And Diabetes

    Lowering the "bad" form of cholesterol with statin drugs could increase diabetes risk, a study suggests. Scientists found that people with naturally lower levels of low-density lipoprotein (LDL) cholesterol were less likely to develop heart disease but slightly more vulnerable to Type 2 diabetes. Reducing LDL levels by taking statins may have the same effect, they believe. Lead researcher Dr Michael Holmes, from Oxford University, said: "What we' ...

    diabetes Dec 27, 2017
  • Is There A Link Between Diabetes And Glaucoma?

    Diabetes is a complex disease resulting from the inability of the body to produce insulin, a hormone that takes sugar out of the blood and into cells where it can be used for energy. Without enough insulin, there is too much sugar in your blood. It’s like having a car full of gas but no key; you have the fuel you need, but can’t start using it. Diabetes affects more than 29 million Americans. The most common form of diabetes is adult-onset di ...

    diabetes Jan 4, 2018
  • Is There A Link Between Diabetes And Gout?

    Women with this form of arthritis are more susceptible, researchers say Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. And "More information" links may no longer work. Questions about personal health should always be referred to a physician or other health care professional. HealthDay Reporter FRIDAY, Oct. 3, 2014 (HealthDay News) -- Gout, a ...

    diabetes Jan 5, 2018
  • What Is The Link Between Diabetes And Hypertension?

    Abstract Diabetes mellitus and hypertension are common diseases that coexist at a greater frequency than chance alone would predict. Hypertension in the diabetic individual markedly increases the risk and accelerates the course of cardiac disease, peripheral vascular disease, stroke, retinopathy, and nephropathy. Our understanding of the factors that markedly increase the frequency of hypertension in the diabetic individual remains incomplete. Di ...

    diabetes Dec 30, 2017
  • Is There A Link Between Diabetes And Heart Disease?

    3. Diabetes-CVD Facts

    • More than 65% of all deaths in people with diabetes are caused by cardiovascular disease.
    • Heart attacks occur at an earlier age in people with diabetes and often result in premature death.
    3 4. Diabetes-CVD Facts
    • Up to 60% of adults with diabetes have high blood pressure.
    • Nearly all adults with diabetes have one or more cholesterol problems, such as:
  • What Is The Link Between Obesity And Type 2 Diabetes?

    If you’re obese or overweight, then you should know that you’re at a great risk of having type 2 diabetes. According to International Diabetes Foundation, obesity and diabetes are the major health problems of the 21st century. According to a supporting statistics, a person is diagnosed with diabetes every three seconds. The modern lifestyle has a major role in developing type 2 diabetes. Sedentary lifestyle of people lea ds to high fat accumu ...

    diabetes Dec 30, 2017

Popular Articles

More in diabetes