Lantus At Bedtime

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Splitting Insulin Glargine Doses

I’ve been asked (again) about optimizing how to give the dose of Lantus (insulin glargine), so I decided I’ll share my thoughts on-line. First, a disclaimer: (1) I previously worked for Aventis and later Sanofi-Aventis, the manufacturer of Lantus, in the area of pharmacovigilance (drug safety). (2) The advice given here is “off-label” (that is, it’s not approved by the FDA). Lantus is the brand name for insulin glargine, a very long-lasting insulin product that was approved by the FDA in 2000; it was first sold in the US in 2001 and is now available world-wide. It was originally marketed as “peakless”, but the marketing folks soon changed the wording to “no pronounced peak.” The whole idea was that Lantus lasts longer than a day, so if you inject it once daily, the previous day’s dose is still lingering, and smoothing out the action of the insulin. (BTW, logically, if only one dose of the insulin were to be given, and no other insulin doses, every insulin, including Lantus, would have a beginning, a peak, and then a decay to no-activity sooner or later.) However, many patients and their physicians noted that even with its long duration of action, Lantus does hav Continue reading >>

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Popular Questions

  1. PCroizier

    My SO is a type 1 diabetic. He used to take lantus in the am but by the next am his blood sugar was very high and he had bad attitude mornings. Now he takes in in the pm and has much stabler blood sugars during day and night. Maybe the patients have different orders based on what's been proven to work for them in the past.

  2. meanmaryjean, DNP

    I am a diabetes resource nurse in my peds hospital, and my grandson has diabetes. Lantus can be given morning, afternoon or evening - doesn't matter as long as it's at the same time every day.

  3. Happy2beICU-RN

    I think you just answered your own question
    If a lot of older diabetics wake up with extremely high blood sugar, Lantus would be beneficial for that person. I did a clinical in nursing school at a LTC facility and we had to administer Lantus in the am. My father however receives it in the evening and it is very effective for him that way. From what I understand about Lantus it isn't necessarily supposed to have a peak. But from what I have seen, Latus is most often administered at night.

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