In What Ways Is Diabetes Insipidus Similar To Diabetes Mellitus

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Vasopressin Contributes To Hyperfiltration, Albuminuria, And Renal Hypertrophy In Diabetes Mellitus: Study In Vasopressin-deficient Brattleboro Rats

Abstract Diabetic nephropathy represents a major complication of diabetes mellitus (DM), and the origin of this complication is poorly understood. Vasopressin (VP), which is elevated in type I and type II DM, has been shown to increase glomerular filtration rate in normal rats and to contribute to progression of chronic renal failure in 5/6 nephrectomized rats. The present study was thus designed to evaluate whether VP contributes to the renal disorders of DM. Renal function was compared in Brattleboro rats with diabetes insipidus (DI) lacking VP and in normal Long-Evans (LE) rats, with or without streptozotocin-induced DM. Blood and urine were collected after 2 and 4 weeks of DM, and creatinine clearance, urinary glucose and albumin excretion, and kidney weight were measured. Plasma glucose increased 3-fold in DM rats of both strains, but glucose excretion was ≈40% lower in DI-DM than in LE-DM, suggesting less intense metabolic disorders. Creatinine clearance increased significantly in LE-DM (P < 0.01) but failed to increase in DI-DM. Urinary albumin excretion more than doubled in LE-DM but rose by only 34% in DI-DM rats (P < 0.05). Kidney hypertrophy was also less intense in DI Continue reading >>

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Popular Questions

  1. Anafry

    How does the mechanism by which diuresis occurs with diabetes insipidus differ from that which occu?

    How does the mechanism by which diuresis occurs with diabetes insipidus differ from that which occurs in diabetes mellitus?

  2. KA kaismama

    In diabetes insipidus its the failure of the kidneys to respond to Anti diuretic hormone. In diabetes mellitus its a response to all the sugar in your blood, trying to get rid of it.

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