Hypothesis Of Diabetes Mellitus

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Testing The Accelerator Hypothesis

The relationship between body mass and age at diagnosis of type 1 diabetes Abstract OBJECTIVE—Previous reports have predicted greater risk of type 1 diabetes among people who were heavier as young children. The Accelerator Hypothesis predicts earlier onset in heavier people, without necessarily a change in risk, and views type 1 and type 2 diabetes as the same disorder of insulin resistance, set against different genetic backgrounds. Insulin resistance is a function of fat mass, and increasing body weight in the industrialized world has been accompanied by earlier presentation (i.e., acceleration) of type 2 diabetes. We wanted to establish whether increasing body weight was also asociated with the earlier presentation of type 1 diabetes, as the Accelerator Hypothesis would predict. RESEARCH DESIGN AND METHODS— The relationships between fatness and age at diagnosis were examined in context of birth weight, weight change since birth, weight at diagnosis, BMI at diagnosis, and BMI 12 months later in 94 children aged 1–16 years (49 boys and 45 girls) presenting for management of acute-onset type 1 diabetes. RESULTS—BMI standard deviation score (SDS) at diagnosis, weight SDS cha Continue reading >>

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Popular Questions

  1. Scarlet Phantom

    Dawn Phenomenon - Can it be 'cured' ?

    This has always been my biggest problem... Even when my diabetes was under tight control.
    I was wondering... anyone got rid of DP? Or what did you do to make it somewhat better? Can it be 'cured'?
    Thanks for your feedback!

  2. foxl

    Not sure about cured, but mine has gone down about 20 pts by cutting back my caffeine intake.
    DP is all about the adrenal gland -- anything you do to lower adrenal secretion of cortisol is helpful.

  3. henword


    Originally Posted by Scarlet Phantom
    This has always been my biggest problem... Even when my diabetes was under tight control.
    I was wondering... anyone got rid of DP? Or what did you do to make it somewhat better? Can it be 'cured'?
    Thanks for your feedback! Scarlet,
    You could switch to an insulin pump. I've only been on one for 4 mos. but I am surprised that morning BGs of 200+ are becoming increasingly rare. Go back a few years and I was getting morning BGs of 250 almost daily, even with a1cs below 7.0. Of course there's a lot involved with switching to the pump, but if you want to make the adjustment and your insurance goes along with it, I recommend it.

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