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How Does The Liver Affect Blood Sugar Levels?

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What Causes The Blood Glucose Level To Increase In Liver Damage?

Chronic liver damage can result in the replacement of normal liver tissue with non-functioning scar tissue. Advanced liver damage is called cirrhosis, and glucose intolerance is a common feature of this condition. An article in the January 2009 issue of the “World Journal of Gastroenterology” reports that greater than 90 percent of people with liver cirrhosis are glucose intolerant, and nearly 30 percent will develop diabetes. Liver cirrhosis is irreversible and can be the result of alcoholic liver disease, hemochromatosis, non-alcoholic fatty liver disease or chronic hepatitis C infection. Video of the Day The liver is the primary disposal site of insulin; when the liver is damaged, less insulin is taken up and degraded, causing a condition of chronic hyperinsulinemia. A study in the July 1998 issue of “Hepatology” reports that hyperinsulinemia in patients with liver cirrhosis causes muscle insulin resistance. Another study in the March 1994 issue of “Hepatology” reports patients with cirrhosis exhibit metabolic abnormalities consistent with muscle tissue insulin resistance. This means that in people with impaired liver function, glucose is not as efficiently removed f Continue reading >>

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Popular Questions

  1. User25259

    Liver Dump: In a Nutshell!

    I've read bits and pieces about this liver dump theory/condition, and would like someone, anyone to give me a short synopsis, or snapshot of just what exactly a "Liver dump" is; how to prevent it one from happening; and the pros and cons of a liver dump!
    Thanks for the info, it will be nice to have a short and sweet answer to what it is and how to know if it happens.
    Pastor Paul

  2. Nan OH

    Liver Dump is when your body thinks it is in need of fuel - glucose that is stored in the liver is released to fuel you up. Pros - not a thing a diabetic wants. Cons - high BGL in the morning. I can modify my glucose release by eating a small bowl of cereal with real sugar as a bed time snack (I use insulin). Don't think it can be prevented at all.
    This is not a part of our normal attempt to get control - it usually happens while we sleep because that is the longest time we go without eating. Clear as Mud? Sorry

  3. smorgan

    Liver dumps are insulin the result of resistance of the liver. At various times as others have described - most notably at dawn - signals are sent out for the liver to release glycogen from its stores as glucose. In a normal system, the first release of glucose triggers a release of insulin from the pancreas. Shepherding glucose into cells for energy is not insulin's only job. It also 1) pushes fat into storage and inhibits its release and 2) encourages storage of glucose as glycogen in the liver AND inhibits or stops its release.
    So, in a type 2, normal hormone signals which would only cause a slight (and beneficial) rise in blood sugar cause a higher spike. This is because the liver responded to those other hormones but its response to insulin is impaired - hepatic insulin resistance - and so it releases more than it should, i.e., doesn't know when to stop.
    I avoid this by keeping my glycogen stores depleted. Depleting them is a prerequisite for getting into ketosis and since I stay in ketosis virtually all the time, no liver dumps. If I come out of ketosis - even though still eating very much "low-carb" and with good numbers throughout the day, Dawn Phenomenon will return and if breakfast is delayed, my BG will drift slowly up instead of its normal down or steady state.
    Others have various other tricks for getting around the broken hormone signaling/response.

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