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How Do You Assess For Somogyi Phenomenon?

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Somogyi Effect (rebound Hyperglycaemia)

An insulin dose that is too high may bring about the Somogyi effect or rebound hyperglycaemia. This can also be produced if blood glucose concentrations fall too rapidly. The body attempts to counteract the decline in the blood glucose concentration through a chain of reactions: The blood glucose concentration falls rapidly or approaches hypoglycaemia (blood glucose concentrations of less than 5 mmol/l (90 mg/dl)) following the injection of insulin. The animal becomes hungry and either restless or lethargic. In response to a declining blood glucose concentration in the CNS, adrenaline and subsequently cortisol, glucagon and growth hormone are released. These hormones bring about an increase in the blood glucose concentration (through gluconeogenesis, release of glucose from hepatic glycogen and increased peripheral resistance to insulin). The resultant hyperglycaemia produces polyuria and polydipsia. This can easily be misinterpreted as a result of an inadequate insulin dose. If the morning polyuria is thought to be the result of an insufficient insulin dose and a higher dose is given, the problem will be aggravated. An even more pronounced Somogyi effect will follow. Eventually th Continue reading >>

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  1. Nicole2010

    "response tp excessive dose of insulin. is a hypoglycemic condition that usually occurs in the predawn hrs of 2-4am. there is a rapid decrease in blood glucose which stimulates a release of hormones (eg cortisol, glucagon, epinephrine) to increase blood glucose by lipolysis, gluconeogenesis, & glycogenolysis. blood sugars must be monitored between 2-4 am & reduce the bedtime insulin level"
    this is straight from the pharm book

  2. missjennmb

    that sounds like another language lol
    wonder what it means in English

  3. ghillbert

    Basically means rebound hyperglycemia. Your blood glucose level drops too low overnight, and to compensate the body over-reacts by releasing a whole bunch of chemicals which result in elevated blood sugar in the morning.
    Way to avoid the rebound is to avoid the hypo - may mean timing or dosing the night time insulin differently.

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