How Can Diabetes Lead To Kidney Failure

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Diabetic Nephropathy

Diabetic nephropathy (diabetic kidney disease) (DN)[1] is the chronic loss of kidney function occurring in those with diabetes mellitus. It is a serious complication, affecting around one-quarter of adult diabetics in the United States. It usually is slowly progressive over years. [2] Pathophysiologic abnormalities in DN begin with long-standing poorly controlled blood glucose levels. This is followed by multiple changes in the filtration units of the kidneys, the nephrons. (There are normally about 3/4-1 1/2 million nephrons in each adult kidney).[3] Initially, there is constriction of the efferent arterioles and dilation of afferent arterioles, with resulting glomerular capillary hypertension and hyperfiltration; this gradually changes to hypofiltration over time.[4] Concurrently, there are changes within the glomerulus itself: these include a thickening of the basement membrane, a widening of the slit membranes of the podocytes, an increase in the number of mesangial cells, and an increase in mesangial matrix. This matrix invades the glomerular capillaries and produces deposits called Kimmelstiel-Wilson nodules. The mesangial cells and matrix can progressively expand and consume Continue reading >>

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Popular Questions

  1. Allison Stasiuk

    I'd recommend none if you have diabetes, kidney disease, high blood pressure or are on medications like ACEIs (ends in "pril", ramipril, perindopril etc.) or ARBs (the "sartans", telmisartan, irbesartan etc.) Since it can lead to kidney failure as well as increased risk of cardiovascular events (small but significant risk), such as heart attack and strokes.
    But if you're young and healthy, watch your stomach lining (these meds can cause ulcers, and stomach bleeds), but otherwise it should be safe.

  2. Catherine Oates

    It depends on what you're taking it for. The bottle gives dosage instructions, but don't use it to mask pain that might be telling you that something needs to be addressed.

  3. Joshua Carr

    I've interpreted this question in a different way to the others here.
    An Ibuprofen overdose is quite an impressive feat. The average man would have to take roughly 150 200mg tablets to overdose and toxic effects are not likely below 100mg/kg. If you start to even come near such a high dose you will begin to feel very ill as the ibuprofen messes with your stomach.
    I imagine the answer you're looking for is one that's already been provided but I thought I'd provide this one too. Just in case!

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