Genetic Determinants Of Diabetes

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Identifying Genetic Determinants Of Diabetes In African Americans

Identifying Genetic Determinants of Diabetes in African Americans Posted on: June 28, 2016 Topics: Type 2 diabetes The global burden of type 2 diabetes is borne disproportionately by people of non-European ancestry, especially African Americans. But those racial and ethnic disparities have received little attention from genetics researchers. Now, a new multi-ethnic study by an international team, led by researchers from the School of Public Health and Massachusetts General Hospital, has found that African Americans and whites share some genetic determinants of Type 2 diabetes, while also carrying some unique genetic loci. The study, published online in the American Journal of Human Genetics , found that about half of gene variants identified in people of European ancestry were shared by African Americans, suggesting that genetic determinants of human glucose regulation are more similar than different across human populations. The study also identified two new genetic variants, bringing to 56 the number of Type 2 diabetes fasting-glucose and fasting-insulin-associated loci. Ching-Ti Liu, a lead author and associate professor of biostatistics, said the study is an important step to Continue reading >>

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Popular Questions

  1. LoveSweets

    A1C is 6.4......now what?

    So, FINALLY I talk with the nurse at the doctor's office today who tells me that the doctor said I am slightly diabetic. Hmmm.....is there such a thing? Anyway, I ask for a number because I knew that would mean something to you folks here. My A1C is 6.4. I have an appointment to go in and talk with the doctor next week. Meanwhile i was cautioned to lower my carb intake.
    What sorts of questions should I ask?
    Is is feasible that I could manage this with exercise and diet so that I don't have to go on medication?
    So my plan is to continue watching my carbs til the appointment. I will also ask for a referral to a nutritionist or some sort of thing like that. I am so much better off when I HEAR something, as opposed to reading it. All this internet reading has just sort of confused me.
    I absolutely need to take this seriously. I do not want to end up like my uncle who had some sort of surgery by died because of some complications that his diabetes had caused.
    I will not be like my mother who continues to be in denial about the damage her smoking has caused, despite the fact that she had her bladder removed because of cancer, has had carotid artery surgery, as well as major vascular bypass surgery and emphysema.....she still has her head in the sand and refuses to believe the smoking caused it.
    I wan to learn. I want to be informed and know what I can do so that I can head off problems in the future. I have seen first hand how "successful" denial is.
    So......fire away.....let me know what numbers I should get from the doctor. What should I ask her.
    Thanks so much. It is such a comfort to have this community.

  2. User2013

    There is no such thing as slightly diabetic however I would say you are a new diabetic meaning you just found out. Good advice to lower carb intake. Also portion control which means you need to know what serving sizes are. A little book called Calorie King, web site is www.calorieking.com, has thousands of food listings with carbs and serving sizes, also a resturant guide and fast food. Helpful little book.
    Take some small steps with this, lowering carbs, type of carbs and serving sizes. Find some type of exercise, walking is great. Test 1 and 2 hours after eating for about a week to see what foods spike you up and what is acceptable. Keep a log of your numbers and what you ate and you will soon see a pattern. That's enough to get you started and I am sure more folks will come along with much more but be careful about information overload and becomming overwhelmed.
    As for your mom, my 63 year old sister died this morning from lung cancer. Had only found out 3 months ago because she choose to ignore the warning signs of being in trouble from smoking. Let me tell you, these last 3 months have been a living hell. She is now finely in peace. We all make our own choices, some are not real good and some we learn from.

  3. jwags

    The first thing you need to get is a bg meter. If you have good insurance, get an Rx for one. Otherwise find one at Walmart or online that has cheap strips. You then will want to test when you wake up and before and 2 hours after meals. Ideally you want to be close to 100 or below when you wake up. After meals no higher than 120-140, preferably lower. If you have high morning bgs but after meal bgs are OK I would talk to the doctor about metformin. It works in the liver to control those high morning bgs. A lot of us have found that Low Carb diets work best with pre D's and early diabetics to get numbers down quickly. Unfortunately the medical community will not tell you that Low Carb works. Most dieticians will give out a higher carb diet and tell you it is still ok to eat lots of processed carbs. For most of us eating carbs means a bg spike. If you can find how much your pancreas can tolerate at one meal , then you can contol bgs and lower HbA1c. Also if you are not currently exercising start. In the beginning 30 minutes a day should be fine, but gradually work it up to an hour or so.

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