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Diabetic Ketoacidosis Treatment

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Diabetic Ketoacidosis

Also known as: DKA Severe diabetic ketoacidosis is a medical emergency and requires prompt treatment to correct dehydration, electrolyte disturbances and acidosis. It is a complication of insulin dependent Diabetes Mellitus. DKA is the result of marked insulin deficiency, and ketonaemia and ketoacidosis occur approximately 15 days after insulin concentrations are suppressed to fasting levels. Marked insulin suppression occurs on average 4 days after fasting glucose levels reach 30mmol/L. Many cats with DKA have other intercurrent conditions which may precipitate the condition including: infection, pancreatitis or renal insufficiency. Pathophysiology Insulin deficiency leads to increased breakdown of fat that releases fatty acids into the circulation. Free fatty acids are oxidised in the liver to ketones that are used by many tissues as an energy source instead of glucose. This occurs when intracellular levels of glucose are insufficient for energy metabolism as a result of severe insulin deficiency. In the liver, instead of being converted to triglycerides, free fatty acids are oxidised to acetoacetate, which is converted to hydroxybutyrate or acetone. Ketones are acids that cause Continue reading >>

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  1. Karan Sharma

    Diabetes

    Medical Conditions and Diseases

    Medicine and Healthcare



    What are the first complications of diabetes?




    1 Answer







    There are a number of complications that can develop in long term diabetics.
    One of the earliest complication that can be seen in an Undiagnosed Type I diabetic is Diabetic Ketoacidosis (DKA)[1].
    In diabetics on treatment, hypoglycaemia is also a common complication that can occur.
    Footnotes
    [1] Causes, Symptoms and Treatment of DKA

    168 Views · 1 Upvote








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