Diabetes And Wound Healing Pathophysiology

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Engineered Biopolymeric Scaffolds For Chronic Wound Healing

1Gemstone Biotherapeutics, Baltimore, MD, USA 2Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA Skin regeneration requires the coordinated integration of concomitant biological and molecular events in the extracellular wound environment during overlapping phases of inflammation, proliferation, and matrix remodeling. This process is highly efficient during normal wound healing. However, chronic wounds fail to progress through the ordered and reparative wound healing process and are unable to heal, requiring long-term treatment at high costs. There are many advanced skin substitutes, which mostly comprise bioactive dressings containing mammalian derived matrix components, and/or human cells, in clinical use. However, it is presently hypothesized that no treatment significantly outperforms the others. To address this unmet challenge, recent research has focused on developing innovative acellular biopolymeric scaffolds as more efficacious wound healing therapies. These biomaterial-based skin substitutes are precisely engineered and fine-tuned to recapitulate aspects of the wound healing milieu and target Continue reading >>

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Popular Questions

  1. [deleted]

    Blood Sugar During Water Fasting

    Is it okay to take a tea spoon of sugar while water fasting when blood sugar is too low1. Will it mess up water fasting process? I am way too overweight 130kg 5.10ft and was recently diagonised with diabetes 2. I want to consider water fasting for a month. I believe I wont go under low blood sugar level during the water fast because Normally my blood sugar is way too high as well 10-16 mmol/l most times.but I really want to improve my health and my weight. ofcourse if it's not okay I will go water fasting but will stop once my sugar levels are low.

  2. JorgePasada

    First and foremost, if you're diabetic you should consult with and be regularly monitored by your physician while fasting.
    And yes, if your blood sugar goes too low while fasting you should ABSOLUTELY consume sugar. Break the fast, and reset your body. If you're self administering insulin, you will have to lower your dose (under the guidance of your physician) while fasting.
    I highly recommend reading Dr. Fung's book 'The Complete Guide to Fasting' as there is extensive information on treating type 2 diabetics as well as general fasting and health tips.

  3. [deleted]

    i am not sure which type is my diabetes given to me by my doctor. I just take medicine, I dont take any insulin.

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