Brain Damage Type 1 Diabetes

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Type 1 Diabetes And The Brain

Is the presence and development of microvascular disease in type 1 diabetes related to changes in brain structure and cognitive function? 2006-.... Funding: Dutch Diabetes research Foundation. Contact person: Eelco van Duinkerken There is growing evidence that individuals with type 1 diabetes (DM1) have mild performance deficits in a range of neuropsychological tests compared to non-diabetic controls, but the mechanisms underlying cognitive deterioration in diabetes are still not fully understood. In the past decades, several studies have addressed the effects of recurrent hypoglycemia on cognition. While retrospective studies in adult patients with DM1 have demonstrated an association between a history of recurrent severe hypoglycemia and a modest degree of cognitive impairment, two large prospective studies did not find such an association. Reanalysis of the DCCT findings confirmed this conclusion. In contrast, there is evidence emerging for a damaging effect of chronic hyperglycemia on brain function. Hyperglycemia may lead to accumulation of potentially toxic glucose metabolites, oxidative stress, accelerated formation of advanced glycation end products and microvascular change Continue reading >>

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  1. Richard157

    Diabetes and Brain Damage

    This was a very popular thread on another diabetes website so I thought I might give it a try here. I will start by giving a little of my own experience with this topic and my initial rejection of the idea that hypos could cause brain damage. My opinion has changed since that time!
    In the mid-70's I had a doctor, a GP, who had moved to the U.S. from Germany. He asked me many questions about my diabetes. He told me that hypoglycemic episodes can cause brain damage. I assumed that he was using scare tactics to make me work for better control. Now that so much more is known about diabetes and we have this wonderful tool, the computer, at our finger tips, I have researched this topic. I researched "diabetes and brain damage" on a search engine and found a site entitled "Diabetes Self-Management-Hypoglycemia and Brain Damage".
    Yes, very bad hypoglycemic reactions do seem to cause brain damage but it is usually temporary. In some instances, however, a more permanent memory loss can occur.

  2. Tiger Lily

    well, in relation to hypos, i was recently reading that vision loss can occur as a result of hypos.....
    i'm not sure i believe long term brain damage can occur unless we are talking about hypos where the patient goes into seizures and goes unconscious for hours or days at a time
    what level of hypo were you talking about?

  3. tralea

    Well, I think that if you're having lows to the point of severe hypounawareness, then I think it's probably possible to suffer brain damage.

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