Diabetes Medications That Cause Weight Loss

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Intentional Weight Loss And Dose Reductions Of Anti-diabetic Medications – A Retrospective Cohort Study

Abstract Intentional weight loss, primarily by improving insulin resistance, is known to decrease the need for anti-diabetic medications. In this study, we assess the magnitude of weight loss that resulted in dose reductions or discontinuation of anti-diabetic medications in overweight or obese patients with type 2 diabetes (DM) undergoing weight loss treatment. Case records of 50 overweight or obese patients with DM who successfully decreased dosage or discontinued diabetes medications after losing weight via attendance at two University-based, outpatient weight management centers were analyzed. Follow-up visits, weight reduction interventions, and decisions for dose reductions or discontinuation of medications were individualized to patient needs by the treating physician. Results Mean starting BMI was 35 kg/m2, mean age 53.4 years, and 58% were male. All 50 used at least one anti-diabetic medication (30 metformin, 39 sulfonylureas, 31 insulin, 21 sitagliptin) to manage blood sugar. Mean duration of follow-up was 30.2 months. Mean weight loss was 10.8±4.1 kgs (11.1% of initial body weight ±4.7%). 22/50 patients (44%) discontinued anti-diabetes medications (14 sulfonylureas [36% Continue reading >>

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Popular Questions

  1. Wraakian

    "I've type 2 diabetes for over 30 years & until recently only on oral medications. 2 months ago I was put on Victoza to control the increasing blood glucose levels of 18mmol/l (325mg/dl) that I now was experiencing. The diabetic nurse gave me 0.6 dose of Victoza, kept me on my daily 2000mg Metformin, took me off sitaglyptin & reduced my 320mg Gliclazide to 240mg /day. My highest blood glucose levels dropped to 13mmol/l, but when having carbs didn't go down to near 6.7mmol/l. Increasing my Victoza to 1.2 after 2 weeks proved no better, I tried 1.8 Victoza again without success. I'm back to 1.2 dose + 2000 metformin + 340mg Gliclazide. Initially I lost my appetite and felt nauseous with Victoza. What next? (UK)"

  2. Lilyall4me

    "I've been on Victoza for 5 weeks. First week at 0.6 and then 1.2. I have lost about 15 lbs. thus far. While my appetite has been curbed by the medicine, I've also made a great deal of effort to watch what I eat. While I've experienced many of the symptoms that others have (nausea, burping, tiredness) they have been mild and quite tolerable. My doctor advised me that many of the digestive issues that people experience are as a result of overeating while on the medication. I stop eating as soon as I feel full and I'm usually good. My glucose numbers have decreased enough, but that might be just because of the significant difference in my diet."

  3. MBDub

    "Just started this med 2 weeks ago. I feel awful: generally ill feeling (like a cold or flu), severe headache, nausea, vomiting, muscle cramping (feels like I've done a massive workout and let the muscles cool down without stretching), muscle weakness (where it's a chore to lift arms and legs...skin pain, too), trouble sleeping, I can feel my heart pounding and hear it in my ears, coughing, and I don't know what else. I have spoken to my doctor and been told this will go away, but I'm concerned. My vision wasn't great before, but seems worse now. Not sure what to do..."

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