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Can Metformin Be Taken Once A Day?

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One Of The Most Effective Diabetes Drugs

You may recall that I recently wrote a series on various medicines and how they can affect your diabetes (see "The Ups and Downs of Meds and Diabetes [Part 1]" as well as Part 2, Part 3, Part 4, and Part 5). One kind reader, who happens to be a nurse, asked me to devote a post to metformin with regard to its effects on kidneys and special considerations to keep in mind with this drug. I wrote about metformin back in December 2006 (was it that long ago?) and its link to vitamin B12 deficiency (see “Metformin and Risk For Vitamin B12 Deficiency”). But there are other important facts to know about this very popular diabetes drug. Raise your hand if you take metformin. OK, obviously I can’t see you, but I’ll wager that many of you reading this are on this medication. Metformin is the generic name for Glucophage, Glucophage XR, Glumetza, Fortamet, and Riomet. It also comes combined with other diabetes medications, including glyburide (in Glucovance), glipizide (in Metaglip), rosiglitazone (in Avandamet), pioglitazone (in Actoplus Met), sitagliptin (in Janumet), and repaglinide (in PrandiMet). I’ve read that approximately 35 million prescriptions were written for metformin in 2 Continue reading >>

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Popular Questions

  1. bkeller39

    I was just prescribed Metformin 500 mg. for the first time, to be taken once a day. When is the best time of day to take it? My resting this morning was 114...should I still take it?

  2. Talvie

    bkeller39:
    I was just prescribed Metformin 500 mg. for the first time, to be taken once a day. When is the best time of day to take it? My resting this morning was 114...should I still take it? My only suggestion about when to take it is after a meal, not because it will bring your blood sugar down from the meal, metformin doesn't work that way, but because it sometimes causes stomach upset in the beginning, and having a full stomach may help with that. 500mg is a minimal dose, so it might not happen, but if you do experience stomach issues, it's rarely for more than two or three weeks. If the discomfort persists, there is an extended release version that usually clears that right up. I've been taking metformin for many years, and am currently on 500mg a day, and I've never had an issue. Most people don't, and with luck, you'll be one of those people, too. :) Sorry you had to join our club, but glad you found us.

  3. maryd98

    bkeller39:
    I was just prescribed Metformin 500 mg. for the first time, to be taken once a day. When is the best time of day to take it? My resting this morning was 114...should I still take it?
    Hi, bkeller39, and welcome to the site!
    Most people find that taking metformin with food usually helps with the gastric side effects...and so does taking the extended release version. (Just a heads up in case you end up feeling those side effects.)
    I would think that before bed (with a snack?) might possibly be the best time to take metformin because the main way it works is by keeping the liver from releasing too much glucose.
    Even though your fasting BG this morning was 114, I suggest you start taking it since it was prescribed for you....of course, it's your decision, but....it's entirely possible for people with diabetes to have their fasting BG at 114 or lower and still be helped by metformin. It might be that your BG is much higher at other times of the day. Do you ever test at other times?

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